Theme 2 investigators are basic scientists probing the cellular and molecular basis of adaptive and innate immunity critical to mucosal defense. Given the intense relationship between the immune system and lumenal microbes that plays out across the intestinal epithelial barrier, it is not surprising that there is considerable overlap and collaboration of investigators in this group with Theme 1 (epithelium) and Theme 3 (microbiota).
| HDDC Principal Member | Institution | Specific Research Focus |
| Blumberg, Richard, MD | BWH | Role of intestinal epithelium in mucosal immunology |
| Chiu, Isaac, PhD | HMS | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Horwitz, Bruce, MD, PhD | BCH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Huh, Jun, PhD | HMS | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Kagan, Jonathan, PhD | BCH | Intracellular signaling in innate anti-microbial immunity |
| Mathis, Diane, PhD | HMS | Effects of gut microbiome on immune system function |
| Moffitt, Jeff, PhD | BCH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Ordovas-Montanes, Jose, PhD | BCH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Rakoff-Nahoum, Seth, MD, PhD | BCH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Snapper, Scott, MD, PhD | BCH/BWH | Genetics and regulatory T cells in inflammatory disease |
| von Andrian, Ulrich, MD, PhD | BCH | Visualizing lymphocyte migration and interactions in vivo |
| Waldor, Matthew, MD, PhD | BWH | Cell biology and virulence genes of enteric pathogens |
| Zanoni, Ivan, PhD | BCH | Innate immune cell signaling in inflammatory disorders |
| HDDC Associate Member | Institution | Specific Research Focus |
| Benoit, Christophe | HMS | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Chatila, Talal, MD | BCH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Geha, Raif, MD | BCH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Huang, Yu-Hwa, PhD | BWH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Kean, Leslie, MD, PhD | BCH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Pyzik, Michal, PhD | BWH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Quintana, Francisco, PhD | BWH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Raychaudhuri, Soumya, MD, PhD | BWH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Samuelson, John, MD, PhD | BU | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Sethi, Nilay, MD, PhD | DFCI | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Sharpe, Arlene, MD, PhD | BWH/HMS | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |
| Weiner, Howard, MD | BWH | Innate and Adaptive Mucosal Immunology & Microbial Pathogenesis |