The HDDC members active in this group are basic cell and developmental biologists, including a strong group of stem cell and tissue engineering biologists, who are broadening and deepening the longstanding focus of the HDDC on intestinal epithelial cell biology.
| Leaders: David Breault, MD, PhD & Wayne Lencer, MD | ||
| HDDC member | Institution | Research focus |
| Alper, Seth, MD, PhD | BIDMC | Epithelial, Developmental and Stem Cell Biology |
| Bass, Adam, PhD | DFCI | Epithelial, Developmental and Stem Cell Biology |
| Bhatia, Sangeeta, MD, PhD | BCH | Generation of 3D liver organoids to study hepatic infections |
| Breault, David, MD, PhD | BCH | Intestinal stem cells in epithelial renewal and cancer |
| Camargo, Fernando, PhD | BCH, HU | Liver stem cell activity, regenration and organ size |
| Carrier, Rebecca, PhD | NE Univ | Tissue engineered models for study of intestinal physiology |
| Daley, George, MD, PhD | BCH, HMS | Genetics of intestinal stem cell renewal and differentiation |
| Duggan, Christopher, MD | BCH | CLINICAL/TRANSLATIONAL |
| Farese, Robert, MD | HSPH | Cellular lipid metabolism, hepatic steatosis & insulin resistance |
| Goessling, Wolfram, MD, PhD | BWH, DFCI | Initiating signals for liver organogensis, growth and cancer |
| Hagen, Susan, PhD | BIDMC | Gastric epithelial barrier function, H. pylori and cancer |
| Haigis, Marcia, PhD | HMS | Mitochondrial sirtuin control of cellular metabolism |
| Hansen, Steen, DMSc, MD | BCH | E-cadherin-Scrib signaling and epithelial cell survival |
| He, Xi, PhD | BCH | Wnt/beta-catenin signaling in GI stem cell regulation |
| Hofer, Aldebaran, MD, PhD | W Rox VA | cAMP signaling in colonic epithelial pathophysiology |
| Ingber, Don, MD, PhD | BCH, Wyss | Development of “gut on a chip” micro-physiologic cultures |
| Joshi, Neel, PhD | Wyss | Innate and adaptive mucosal immunology |
| Karp, Jeffrey, PhD | BWH, Wyss | Mucosal drug delivery systems for inflammatory disease |
| Kasper, Dennis, MD | BWH | Gut microbiota and lipid effects on mucosal immune function |
| Kirchhausen, Thomas, PhD | BCH, HMS | Molecular analysis of clathrin-mediated endocytosis |
| Lencer, Wayne, MD | BCH | Epithelial membrane traffic and innate responses to toxins |
| Lu, Tim, PhD | MIT | Epithelial, Developmental, and Stem Cell Biology |
| Nissim, Sahar, MD, PhD | BWH | Pancreatic progenitor cells in inflammation and cancer |
| Rosen, Rachel, MD | BCH | CLINICAL/TRANSLATIONAL |
| Shivdasani, Ramesh, MD, PhD | BWH, DFCI | Intestinal epithelial cell differentiation and homeostasis |
| Silver, Pam, PhD | BCH, Wyss | Systems analysis of intracellular signaling circuits |
| Springer, Tim, PhD | BCH | Innate and adaptive mucosal immunology |
| Syngal, Sapna, MD | BWH | CLINICAL/TRANSLATIONAL |
| Tabin, Cliff, PhD | HMS | Epithelial, Developmental, and Stem Cell Biology |
| Turner, Jerrold, MD, PhD | BWH | Innate and adaptive mucosal immunology |
| Yimlamai, Dean, MD, PhD | BCH | Hippo signaling in liver cell differentiation and cancer |
| Associate member | Institution | Research focus |
| Chinnapen, Daniel, PhD | BCH | Intracellular sorting of lipids in intestinal epithelial cells |
| Huang, Yu-Hwa, PhD | BWH | Role of CEACAM1 in tolerance and autoimmunity |
| Popov, Yury, PhD (liver) | BIDMC | Epithelial, Developmental, and Stem Cell Biology |
| Richmond, Camilla, MD | BCH | Quiescence and activation of intestinal crypt stem cells |
| Thiagarajah, Jay, MD, PhD | BCH | Role of aquaporins in colonic epithelial and immune cells |