Theme 3: Gut microbiome & microbial pathogenesis
The HDDC members active in this Affinity group include investigators applying advanced sequencing and informatics to study the commensal gut microbiome and its interaction with the immune system. New and continuing members focused on the commensal microbiome join an accomplished group of established scientists focused on microbial pathogenesis in the intestine and liver.
| Leaders: Lynn Bry & Wendy Garrett | ||
| HDDC member | Institution | Research focus |
| Blaskus, Emily, PhD | HU | Gut microbiome metabolism: role in health and disease |
| Banks, Alexander, PhD | BWH | Role of PPARg phosphorylation in insulin sensitivity |
| Biddinger, Sudah, MD, PhD | MIT | Insulin signaling in liver and control of lipogensis |
| Bry, Lynn, MD, PhD | BWH | Host-commensal-pathogen interactions in the intestine |
| Collins, Jim, PhD | BUSM/Wyss | Systems analysis of antiobiotic effects on gut micriobiota |
| Comstock, Laurie, PhD | BWH | Role of bacteriodales in the intestinal ecosystem |
| Ersoy, Baran, PhD | BWH | Gut microbiome, gnotobiotics, and metabolism |
| Fraenkel, Paula, MD | BIDMC | Hepcidin modulators in human hepatocytes and iron overload |
| Garrett, Wendy, MD, PhD | HSPH | Gut microbiota in immune function and tumorigensis |
| Gerber, Georg, MD, PhD | BWH | Computational modeling of gut microbial communities |
| Greenberg, Andrew, MD | NEMC | Micriobiota and lipid effects on host metabolism |
| Kahn, C. Ronald, MD (Core D) | Joslin | Insulin signaling in gut and liver, and metabolic syndrome |
| Kahn, Barbara, MD | BIDMC | Gut microbiome, gnotobiotics, and metabolism |
| Lee, Chih-Hao, PhD | HSPH | Molecular mechanism governing hepatocyte lipogensis |
| Maratos-Flier, Eleftheria, MD | BIDMC | Gut microbiome, gnotobiotics, and metabolism |
| Paw, Barry, MD, PhD | BCH | Genes involved in liver mitochondrial iron metabolism |
| Rakoff-Nahoum, Seth, MD, PhD | BCH | Inate and adaptive mucosal immunology |
| Shoelson, Steven, MD, PhD | BWH | Gut microbiome, gnotobiotics, and metabolism |
| Spiegelman, Bruce, PhD | DFCI | Gut microbiome, gnotobiotics, and metabolism |
| Tavakkoli, Ali, MB, BS | BWH | Intestinal nutrient transport in diabetes & obesity |
| Associate member | Institution | Research focus |
| Cox, Andrew, PhD | BWH | Hippo pathway in liver development, regeneration, & cancer |
| Feinberg, Mark, W., MD | BWH | |
| Kalaany, Nada, PhD | BCH | Gut microbiome, gnotobiotics, and metabolism |
| Tullius, Stefan, G., MD, PhD | BWH | |