Theme 2 investigators are basic scientists probing the cellular and molecular basis of adaptive and innate immunity critical to mucosal defense. Given the intense relationship between the immune system and lumenal microbes that plays out across the intestinal epithelial barrier, it is not surprising that there is considerable overlap and collaboration of investigators in this Group with Theme 1 (epithelium) and Theme 3 (microbiota).
| Leaders: Edda Fiebiger, PhD & Richard Blumberg, MD | ||
| HDDC member | Institution | Research focus |
| Blumberg, Richard, MD | BWH | Role of intestinal epithelium in mucosal immunology |
| Brigl, Manfred, MD | BWH | Mucosal-Associated Invariant T cells: role in protection |
| Camilli, Andy, PhD | NEMC | Role of c-diGMP signaling in Vibrio cholerae virulence |
| Chatila, Talal, MD | BCH | Role of the intestinal microbiota in tolerance and allergy |
| Fiebiger, Edda, PhD | BCH | IgE-mediated immune activation in mucosal disease |
| Flier, Sarah, MD | BIDMC | Mechanism of intestinal inflammation-associated fibrosis |
| Geha, Raif S., MD | BCH | Primary DOCK8 immunodeficiency in food allergy |
| Goettel, Jeremy, PhD | BCH | Regulatory t cells in control of intestinal inflammation |
| Horng, Tiffany, PhD | HMS | Role of the macrophage inflammasome pathway in IBD |
| Kagan, Jonathan, PhD | BCH | Intracellular signaling in innate anti-microbial immunity |
| Kokkotou, Efi, PhD, MD | BIDMC | Gut hormones and neuropeptides in colitis and cancer |
| Leong, John, PhD | Tufts/NEMC | Interactions of EHEC with intestinal epithelial cytoskeleton |
| Mathis, Diane, PhD | HMS | Effects of gut microbiome on immune system function |
| McCormick, Beth, PhD | U Mass | Pathogen-induced neutrophil migration across epithelia |
| Mekalanos, John, PhD | HMS | Genetic and molecular basis of V. cholerae pathogensis |
| Paster, Bruce, PhD | Forsyth | Oral microbiome for diagnosis and prognosis of IBD |
| Quintana, Francisco, PhD | BWH | Aryl hydrocarbon receptor control of Treg differentiation |
| Raychaudhuri, Soumya, MD, PhD | BWH | Genetics of altered NK T cell function in IBD |
| Sharpe, Arlene, MD, PhD, | BCH, DFCI | T cell costimulatory pathways in tolerance and immunity |
| Snapper, Scott, MD, PhD | BCH, BWH | Genetics and regulatory T cells in inflammatory disease |
| Springer, Tim, PhD | BCH | Innate and adaptive mucosal immunology |
| Starnbach, Michael, PhD | HMS | Mechanism of IFN-gamma control of Shigella infections |
| von Andrian, Ulrich, MD, PhD | HMS | Visualizing lymphocyte migration and interactions in vivo |
| Waldor, Matthew, MD, PhD | BWH | Cell biology and virulence genes of enteric pathogens |
| Weiner, Howard, MD | BWH | Oral tolerance and gut microbiome in auto-immunity |
| Wesemann, Duane, MD, PhD | BWH | Innate and adaptive mucosal immunology |
| Winau, Florian, PhD | BCH | Hepatic stellate cells in immunity and T cell induction |
| Yang, Priscilla, PhD | HMS | Small molecular inhibitors of hepatic and enteric viruses |
| Zanoni, Ivan, PhD | BCH | Innate immune cell signaling in inflammatory disorders |
| Associate member | Institution | Research focus |
| An, DingDing, PhD | BCH | Microbial sphingolipid modulation of iNKT cells |
| Baker, Kristi, PhD | BWH | Intestinal immune regulation by IgG and FcRn |
| Biswas, Amlan, PhD | BCH | Innate and adaptive mucosal immunology |
| Horwitz, Bruce, MD, PhD | BCH | Roles of NfKB, IL-10 and regulatory T cells in IBD |
| Onderdonk, Andrew, PhD | BWH | Human gut microbiota in health and disease |
| Oyoshi, Michiko, PhD | BCH | Immunology of eosinphilic esophagitis and food allergy |
| Surana, Neeraj, MD, PhD | BCH | Effects of the gut microbiota on host immune functions |